Cell competition: Winning out by losing notch

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Cell competition: Winning out by losing notch

Cell competition where 'loser' cells are eliminated by neighbors with higher fitness is a widespread phenomenon in development. However, a growing body of evidence argues cells with somatic mutations compete with their wild type counterparts in the earliest stages of cancer development. Recent studies have begun to shed light on the molecular and cellular mechanisms that alter the competitivene...

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ژورنال

عنوان ژورنال: Cell Cycle

سال: 2014

ISSN: 1538-4101,1551-4005

DOI: 10.4161/15384101.2014.988027